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-synuclein, that is a main ingredient of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, which can be an E3 ubiquitin ligase and leads to endoplasmic reticulum (ER) strain, recommend that dysfunction with the intracellular proteinase techniques, for instance ubiquitin-proteasome system or lysosomal process, which eliminates unneeded ha

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